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    The Role Of Antioxidant Gene Regulation During Bacterial Oxidative Stress Response

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    Title
    The Role Of Antioxidant Gene Regulation During Bacterial Oxidative Stress Response
    Author
    Vu, Lily
    Date
    December 2020
    Subject
    antioxidants
    bacteria
    oxidative stress
    regulons
    ROS
    
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    URI
    http://hdl.handle.net/20.500.13013/791
    Abstract
    Reactive oxygen species (ROS) are produced naturally in a cell and when the cell is in homeostasis, there is an equilibrium of ROS and antioxidants (enzymes that combat ROS). Stresses can occur such as "Oxidative Stress" which results in an influx of ROS compared to antioxidants in the cell and could lead to damage of DNA, lipids and proteins and also cell death. To return the cell’s homeostatic state, bacteria have evolved to contain defense mechanisms to eradicate ROS. This paper will focus on the regulation of antioxidants that are produced to eliminate high concentrations of ROS when the cell is under oxidative stress. These antioxidants are encompassed in a mechanism called a "Regulon," which controls the production of these enzymes. The regulons within this paper include the OxyR, Rpos, SoxRS, PerR, and OhrR regulons. Each regulon plays a critical role in the survival of bacterial species when experiencing oxidative stress. There are many mechanisms such as regulons that help defend the bacterial cell from damage or death from oxidative stress.
    Advisor
    Laranjo, Laura
    Department
    Biology
    Degree
    Bachelor of Science (BS)
    Collections
    Honors Theses
    Biology Honors Theses

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