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    The Role Of T Regulatory Cells In Allergy And Autoimmune Disease And Potential Therapeutic Options

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    Title
    The Role Of T Regulatory Cells In Allergy And Autoimmune Disease And Potential Therapeutic Options
    Author
    Burroughs, Taylor
    Date
    April 2017
    Subject
    adoptive transfer
    allergies
    autoimmune disease
    hygiene hypothesis
    t regulatory cells
    
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    URI
    http://hdl.handle.net/20.500.13013/602
    Abstract
    T regulatory cells are part of the immune system and act to control and suppress immune responses. A small population or a population of T regulatory cells with impaired function has been associated with allergic and autoimmune diseases. Without suppression from these cells, immune dysfunction can become prevalent and lead to disease. Previous studies have shown that exposure to microbes and parasites such as Helminths can boost the T regulatory cell population. In developed countries, where microbial and parasitic exposure is diminished, allergies and autoimmune disorders are on the rise. In this review, scholarly articles and recent clinical trials were examined to see what therapies are currently being tested using T regulatory cells. One of the most favorable therapies is adoptive transfer of T regulatory cells. This therapy has had promising results in the early stages. Patients who received adoptive transfer therapy have had more alleviation of their disease than those in the control groups who received traditional treatment. Future studies need to be done to come to clear conclusions about the effectiveness of adoptive transfer, which would include a larger sample size of patients and longer follow up periods after therapy. By improving our understanding of adoptive transfer as a treatment, patients with these disorders can hopefully have an improved quality of life in the future.
    Advisor
    Scottgale, Gwen
    Department
    Biology
    Degree
    Bachelor of Science (BS)
    Collections
    Honors Theses
    Biology Honors Theses

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