Prolonged Blue Light Exposure Alters Phototransduction Efficiency and One-Carbon Metabolism Processes in the Drosophila Eye

Abstract

Oxidative stress in the eye is associated with the development and progression of ocular diseases including cataracts, glaucoma, age-related macular degeneration, and diabetic retinopathy. This talk focuses on how blue light exposure results in oxidative stress in the Drosophila eye and will discuss proteins that are susceptible to changes in oxidation status and/or redox signaling events. Interestingly, we identified several key phototransduction and one-carbon metabolism proteins with oxidative modifications correlating with changes in enzymatic activity.