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dc.contributor.advisorSprenkle, Amyen_US
dc.contributor.authorMarashio, Kristina
dc.creatorMarashio, Kristinaen_US
dc.date.accessioned2022-09-09T18:37:39Z
dc.date.available2022-09-09T18:37:39Z
dc.date.issued2022-05-01en_US
dc.identifier.urihttp://hdl.handle.net/20.500.13013/2654
dc.description.abstractThere is a dire need for new antibiotics to treat antibiotic resistant bacterial infections. With the assistance of the course-based research experience Tiny Earth, isolates of antibiotic-producing bacteria discovered in BIO 304 Microbiology & Its Applications during Spring 2021 at Salem State University will be further characterized. This characterization may include performing 16S rDNA PCR identification of soil isolates, characterization of the secondary metabolites from these isolates by chemical extraction and testing the metabolites on ESKAPE safe relatives to confirm growth inhibitory activity, and testing the chemical extracts on eukaryotic systems, namely cultured mammalian cells for cytotoxic effects. The ultimate goal of this analysis is to contribute potentially novel antibiotic-producing soil bacterial species to the Tiny Earth database to help in the discovery of new antibiotics.en_US
dc.language.isoenen_US
dc.titleTiny Earth: Studentsourcing Antibiotic Discoveryen_US
dc.typeThesisen_US
dc.description.departmentBiologyen_US
dc.date.displayMay 2022en_US
dc.type.degreeBachelor of Science (BS)en_US
dc.subject.keywordantibioticsen_US
dc.subject.keywordTiny Earthen_US
dc.subject.keywordantibiotic resistanceen_US
dc.subject.keyword16S rRNAen_US
dc.subject.keywordPCRen_US
dc.subject.keywordbacteriaen_US


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